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Sense of smell genetically determined

September 19th, 2007 . by Matt

A given individuals sense of smell is genetically determined by the particular gene variant that they possess, leading people to some people to find some smells pleasant that others find unpleasant.

SMELL is in the nose of the beholder as much as beauty is in the eye, according to a new study showing for the first time that variations in a single gene can determine whether a scent is perceived as fair or foul.
It has long been known that smell and taste – which are essentially the same thing – are highly subjective.

The fragrance that one person finds sublime could make someone else queasy, and one man’s wine of the gods can be another man’s plonk.

A third person might not smell anything at all.

But the exact mechanism accounting for these differences has remained largely a mystery, though genes were known to play a role.

The US study, published online in the British journal Nature, fills in a piece of the puzzle.

Subjects in a “smell survey” conducted by Leslie Vosshall at Rockefeller University in New York judged the intensity and pleasantness of dozens of odours, including a testosterone-derived steroid called androstenone found in human urine and sweat, especially in men.

Most of the respondents said the compound smelled something like “stale urine”. But a significant minority – about 20 per cent – found the odour pleasing, saying it reminded them of vanilla or honey.

Another research team at Duke University in North Carolina, meanwhile, had discovered in laboratory experiments led by Hiroaki Matsunami that androstenone switched on a human odour gene called OR7D4.

Humans have several hundred functional odorant receptor genes, but olfactory sensory neurons in the nasal passage only express, or activate, them one at a time.

In a collaborative effort, the two teams used DNA samples from each of the smell survey participants to sequence the gene that encodes the OR7D4 receptor.

In some of the subjects, they discovered, the gene had undergone a slight mutation called single nucleotide polymorphisms (SNPs) in which a few of the basic, paired building blocks of DNA has changed. This gave rise to two variants of OR7D4.

When they lined up the results of the DNA analysis with the subjective “smell survey”, there was a very strong match between the two sets of groups: those who thought androstenone smelled like old cat pee had one variant of the gene, and those who smelled sweet vanilla had the other.

One Response to “Sense of smell genetically determined”

  1. comment number 1 by: Phil2Musashi

    I have known a couple of girls that were repulsed by the smell of celery. One was like violently repulsed! She could smell it from across the kitchen, and they found the stench over-powering even if there was only a bit of it chopped up fine in soup or stew.